ScienceDaily (July 30, 2010) — Research by the Consejo Superior de Investigaciones CientÃficas (CSIC) and led by Mr Félix Goñi, director of the Biophysics Unit at the CSIC-University of the Basque Country Mixed Centre, has led to the growth of a novel technique of attack after that to the AIDS virus. The technique involves taste a prevention system, i.e. an 'armour' in the evil so as to are probable to be infected and thus impede the virus as of accessing not any and preliminary to act on completely immunological system.
The study, construct appears in the periodical Chemistry & Biology, in print by Cell Press, lays downward the bases of likely prospect pharmaceutical ineffective so as to determination enable combating the AIDS virus at its first phase. Participating in the research, separately as of Mr Goñi, was a side as of the National Biotechnology Centre (CSIC-Universidad Autónoma de Madrid) and one more as of the Institute of Applied Chemistry of Cataloniaa (CSIC, Barcelona). The investigate is feature on the regulation of the fluidity of the cell membranes and seeks to avoid the phenomenon recognized as the fusion of membranes, a consequence of get in touch with recognized by the cell membranes and the membrane of the virus itself. The membrane is the "coating" of the cell cytoplasm and construct protects it as of the outside, and construct has a arrangement similar to so as to of the membranes of the AIDS virus. When together membranes approach eager on contact, and due to the information so as to the cell membrane is extremely "fragile," an orifice is shaped and fusion occurs -- and a way is opened for the AIDS virus to enter, connect to a exact "receptor" of the cell and commence its viral activity. What the checkup are seeking by means of petroleum learn is to make stronger the membrane structure, creation it additional rigid, in arrange to avoid petroleum fusion of membranes and, thus, the inoculation of the cell by the AIDS virus. Practically all action for the AIDS virus at present existence form applied is feature on halting the development of the virus on one occasion it is in,within the host cell. There is but one treatment, commercially recognized as Enfurvitide, construct ,next to discontinue the virus in fact entering the cell. The investigate in print in Chemistry & Biology comes to the similar conclusion, but by a totally dissimilar and novel route. "For the cell membranes and the virus to approach jointly and petroleum orifice be opened to let the entrance of the virus, the membranes contain to contain a sure amount of fluidity, of mobility. We exposed a process to create the cell membranes additional rigid. This might healthy provide go up to a new pharmaceutical medicine construct construct the membranes additional rigid and impede the entrance of the AIDS virus. Instead of the membrane existence form flexible, a type of armour is recognized construct construct the cell impenetrable," explained Félix Goñi. Most of this information comes straight from the pros. Careful reading to the end virtually guarantees that you'll know what they know.The investigate in progress inquisitiveness existence ago and has employed a variety of behavior in the field of chemistry and molecular biology. At the Institute of Applied Chemistry of Catalonia (CSIC, Barcelona), Ms Gemma Fabriàs has synthesised the GT11 molecule by income of organic chemistry synthesis techniques. Mr Santos Mañes, as of the National Biotechnology Centre, studied the viral infection of the cells, and as of the Biophysics Unit at the CSIC-University of the Basque Country labor has person's name everyday jobs at molecular height to demonstrate so as to present are profits in the rigidity of the membranes at what time the GT11 molecule is incorporated eager on them, and so as to at what time the membranes are additional rigid the virus lined fuse by means of the cell membrane and, thus, as of penetrating the cell. A extremely significant position was too located by Mr José Luis Nieva, as of the Biophysics Unit, in studying petroleum fusion of the membranes induced by the AIDS virus. This ,technical discovery by petroleum consortium represents, in the view of Mr Goñi, "a totally new income for attacking the virus, and construct construct petroleum original." "There is medication, and construct is operational extremely well, to avoid the propagation of the virus on one occasion it is in,within the cell. But to impede petroleum inoculation in the primary place, merely one manufactured goods (Enfurvitide) exists, but petroleum medicine is feature on a totally distinct principle. The idea of modifying the rigidity of the membranes is totally new and too demonstrating that, by equipping as,at the same occasion as membranes by means of better rigidity, the AIDS virus lined penetrate," affirmed Mr Goñi. This similar strategy may healthy serve for additional damaging by means of membrane, genuine as, for example, the flu virus.
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Journal Reference:
- Catarina R. Vieira, Jose M. Munoz-Olaya, Jesús Sot, Sonia Jiménez-Baranda, Nuria Izquierdo-Useros, Jose Luis Abad, Beatriz Apellániz, Rafael Delgado, Javier Martinez-Picado, Alicia Alonso, Josefina Casas, José L. Nieva, Gemma Fabriás, Santos Mañes, Félix M. Goñi. Dihydrosphingomyelin Impairs HIV-1 Infection by Rigidifying Liquid-Ordered Membrane Domains. Chemistry & Biology, 2010; 17 (7): 766 DOI: 10.1016/j.chembiol.2010.05.023
Note: If no author is given, the basis is cited instead.
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